Reduced sperm telomere length in individuals with varicocele is associated with reduced genomic integrity
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چکیده
منابع مشابه
Telomere length shortening in chronic myelogenous leukemia is associated with reduced time to accelerated phase.
Telomere shortening is associated with disease evolution in chronic myelogenous leukemia (CML). We have examined the relationship between diagnostic telomere length and outcome in 59 patients with CML who entered into the MRC CMLIII Trial by Southern blot hybridization using the (TTAGGG)(4) probe. Age-adjusted telomere repeat array (TRA) reduction was found to significantly correlate with time ...
متن کاملReduced telomere length in colorectal carcinomas.
PURPOSE Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. The aim of this study was to determine whether telomere length is associated with the colorectal carcinoma. PATIENTS AND METHODS A total of 148 colorectal cancer (CRC) samples and corresponding adjacent non-cancerous tis...
متن کاملReduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis
OBJECTIVE Joint fibrosis affects many synovial joints (including hip, knee and shoulder) causing stiffness and pain. The mechanism of joint fibrosis remains unknown, although genetic factors may contribute. Defects in maintenance of telomere length resulting from impaired telomere repair have been shown to cause lung and liver fibrotic disease. Here we tested the hypothesis that joint fibrosis ...
متن کاملReduced Fetal Telomere Length in Gestational Diabetes
Gestational diabetes mellitus (GDM) is an important complication of pregnancy that poses significant threats to women and their offspring. Telomere length shortens as cellular damage increases and is associated with metabolic diseases. Telomere length in fetal leucocytes was determined in 82 infants of women with GDM (N = 82) and 65 normal pregnant women (N = 65). Women with preeclampsia (N = 4...
متن کاملThe FTO rs9939609 polymorphism is associated with short leukocyte telomere length in nonobese individuals
The fat mass and obesity-associated (FTO) rs9939609 polymorphism have been associated with the increased metabolic risk and mortality, irrespective of obesity. The mechanism underlying this association is not known. We aimed to evaluate whether the FTO rs9939609 risk variant is independently associated with metabolic risk factors and/or leukocyte telomere length (LTL). We further aimed to inves...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-40707-2